Figure 1
Genotype, diet, and sex shape microbiota structure. Differences between microbiota were visualized by PCoA of unweighted UniFrac distances (panels a–e). (a) Overall stratification by diet and mouse genotype. (b) Tg2576 mice show altered microbiota from littermate WT mice, regardless of diet. (c) Diet shifts the microbiota in both WT and Tg2576 mice. (d,e) Male and female mice show differences in microbiota. (b–e) Clusters were significantly different by Permanova test, p < 0.05. (f) Unweighted UniFrac distances between WT and Tg2576 female mice (gray bars) were larger than within genotype distances. (g) CR reduces intragroup microbiota variation compared to AL-fed mice. (h) UniFrac distances between males and females were larger than intragroup distances within each sex. Bonferroni adjusted t-test, *p < 0.05, ***p < 0.001.
