Table 1 Baseline characteristics for the ADNI MCI and the BioFINDER MCS populations and subcohorts.

From: Predicting clinical decline and conversion to Alzheimer’s disease or dementia using novel Elecsys Aβ(1–42), pTau and tTau CSF immunoassays

Characteristic

ADNI

BioFINDER

Overall

(N = 619)

EMCI

(n = 277)

LMCI

(n = 342)

Overall

(N = 431)

SCD

(n = 191)

MCI

(n = 233)

Cohort, N (%)

ADNI1

187 (30.21)

0

187 (54.68)

—

—

—

ADNIGO

117 (18.90)

117 (42.24)

0

—

—

—

ADNI2

315 (50.89)

160 (57.76)

155 (45.32)

—

—

—

Age [years], mean (SD)

72 (7.6)

71 (7.4)

73 (7.6)

70 (5.6)

70 (5.7)

71 (5.5)

Sex, male, N (%)

364 (58.80)

155 (55.96)

209 (61.11)

233 (54.06)

89 (46.60)

142 (60.94)

APOEε4 genotype grouped (number of risk alleles), N (%)

0

314 (50.73)

160 (57.76)

154 (45.03)

234 (54.55)

114 (60.32)

116 (49.79)

1

239 (38.61)

97 (35.02)

142 (41.52)

151 (35.20)

62 (32.80)

86 (36.91)

2

66 (10.66)

20 (7.22)

46 (13.45)

44 (10.26)

13 (6.88)

31 (13.30)

Education [years], mean (SD)

16.09 (2.76)

15.95 (2.65)

16.20 (2.83)

11.8 (3.48)

12.5 (3.56)

11.2 (3.28)

Family history of dementia (first degree), N (%)

Yes

353 (57.03)

167 (60.29)

186 (54.39)

169 (40.92)

79 (42.70)

89 (40.09)

No

260 (42.00)

106 (38.27)

154 (45.03)

244 (59.08)

106 (57.30)

133 (59.91)

Family history of AD (first degree), N (%)

Yes

214 (34.57)

108 (38.99)

106 (30.99)

—

—

—

No

138 (22.29)

25 (9.03)

113 (33.04)

—

—

—

Baseline clinical score, mean (SD)

CDR-SB

1.48 (0.89)

1.29 (0.77)

1.64 (0.94)

—

—

—

MMSE

27.74 (1.81)

28.35 (1.58)

27.24 (1.83)

27.7 (1.81)

28.5 (1.40)

27.1 (1.84)

FAQ

3.06 (4.02)

2.10 (3.20)

3.83 (4.43)

5.67 (5.04)

3.90 (4.39)

6.93 (4.99)

ADAS-cog

16.11 (6.91)

12.70 (5.39)

18.87 (6.77)

—

—

—

Baseline biomarker measurement, mean (SD; pg/mL)

Aβ(1–42)

962.0 (437.0)

1,093 (438.9)

855.7 (406.1)

1,142 (450.5)

1,272 (431.9)

1,038 (439.5)

pTau

27.83 (15.01)

24.25 (13.69)

30.72 (15.42)

23.61 (12.79)

21.62 (11.24)

24.94 (13.55)

tTau

287.0 (134.6)

256.4 (121.7)

311.8 (139.5)

262.9 (119.2)

242.6 (101.9)

276.8 (127.9)

  1. ADNI, Alzheimer’s Disease Neuroimaging Initiative; MCI, mild cognitive impairment; MCS, mild cognitive symptoms; EMCI, early mild cognitive impairment; LMCI, late mild cognitive impairment; SCD, subjective cognitive decline; SD, standard deviation; AD, Alzheimer’s disease; CDR-SB, Clinical Dementia Rating Scale Sum of Boxes; MMSE, Mini-Mental State Examination; FAQ, Functional Activities Questionnaire; ADAS-cog, Alzheimer’s Disease Assessment Scale-cognitive; pTau, phosphorylated Tau; tTau, total Tau.
Back to article page