Figure 8
Effect of myricetin on the uptake of folate by the PCFTs of selected animal species in transient transfectant HEK293 cells. The specific uptake of [3H]folate was evaluated at its concentrations of 5 nM and 5 µM for 2 min at pH 5.5 and 37 °C in the absence of myricetin after preincubation for 60 min in the presence of myricetin (100 µM) or in its absence (control), and subsequently for 5 min in its absence for washout. The data of uptake rate/concentration shown in Panel A are transformed to be presented in % of control for each in Panel B. Data are presented as the means ± S.E. (n = 4). In Panel A, for all the PCFTs, the uptake rate/concentration was significantly smaller at 5 µM than at 5 nM under the control condition (p < 0.05). *p < 0.05 compared with control for each (Panel A) or for comparison between the two concentrations for each PCFT (Panel B).
