Figure 4 | Scientific Reports

Figure 4

From: Ovariectomy increases the incidence and diameter of abdominal aortic aneurysm in a hypoperfusion-induced abdominal aortic aneurysm animal model

Figure 4

Immunohistochemical staining for matrix metalloproteinases (MMPs) and macrophage/monocyte of AAA wall in experiment 1. Abdominal aortic aneurysm (AAA) sac areas from the two experimental groups were divided into those without adipocytes (−) (B,E,H,K,N,Q) and those with adipocytes ( + ) (C,F,I,L,O,R). (A–F) Representative images of immunostaining for MMP-2 (scale bar = 30 µm). (G–L) Representative images of immunostaining for MMP-9 (scale bar = 30 µm). (M–R) Representative images of immunostaining for macrophage/monocyte (scale bar = 30 µm). (S) Quantification of MMP-2 positive areas of the vascular wall. (T) Quantification of MMP-9 positive areas of the vascular wall. (U) Quantification of macrophage/monocyte positive areas of the vascular wall. (S,T) Control ligation group (n = 12), OVX ligation group (n = 8). (T) Control ligation group (n = 11), OVX ligation group (n = 8). Values with different letters are significantly different (P < 0.05). The arrows show the direction of intima and adventitia. In the case of enlarged figure, all layers of arterial wall were not shown.

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