Figure 1

Sample space (N_G × N_T) defined by 10,000 human diseases (columns) and 20,000 protein coding genes (rows). Expanded region comprising 1/10,000tℎ of the whole sample space is enlarged: (a) based on 10th causative genes per disease); (b) (based on 100 causative genes per disease); and c (based on 1000 causative genes per disease). Each cell represents a unique gene-disease pairing. Dark blue cells indicate causal gene-disease pairings, light blue cells druggable gene-disease pairings, with red cells indicating causal and druggable gene disease pairings.