Figure 5 | Scientific Reports

Figure 5

From: Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc

Figure 5

Proteasome inhibition alters glutamine metabolism. (A) Relative mRNA expression levels of MYC, GLS and GLS2 in a panel of HLRCC specimens; (B) Relative mRNA expression levels of MYC, GLS and GLS2 in UOK262 after 24 hours treatment with bortezomib, marizomib and carfilzomib (30 nM); (C) Venn diagrams of the effects of the proteasome inhibitors and siMYC measured by Nanostring-based mRNA expression of 180 metabolic genes. Bort: bortezomib; Mar: marizomib; Carf: carfilzomib; CTL: DMSO control.

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