Figure 1 | Scientific Reports

Figure 1

From: Elevated expression of miR-146a correlates with high levels of immune cell exhaustion markers and suppresses cellular immune function in chronic HIV-1-infected patients

Figure 1

Exhaustion markers and effector function related genes expression of PBMCs from HIV-1 infected and uninfected individuals. RNA were isolated from patients’ PBMCs and analyzed for CTLA-4, TIM-3, LAG-3, GZMB, Perforin and CD107a mRNA levels by quantitative RT-PCR. Total of 205 patients’ samples were analyzed in this study, convincing data of 25 early stage and 37 chronic stage individuals were shown (a–c,g–i). mRNA levels in CD4+ T cell counts < 350 cells/µl group (n = 21) or CD4+ T cell counts ≥350 cells/µl group (n = 16) from chronic stage individuals were compared with healthy controls (HCs) (n = 35) (d–f,j–l). GAPDH was used as an endogenous control. *p < 0.05, **p < 0.01, ***p < 0.001. ns, not significant.

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