Figure 3
From: FABP5 coordinates lipid signaling that promotes prostate cancer metastasis
FABP5 knockdown suppresses metastatic potential in PC3 cells that express FASN and/or MAGL. (A) Migration and invasion of PC3 cells bearing an FABP5 knockdown (white bars) or vector control (grey bars), as well as migration and invasion of PC3 cells treated with vehicle, JZL184 (10 µM), C75 (40 µM), or a combination of both. (B) Overexpression of FASN (red bars) or MAGL (blue bars) increases the metastatic potential of PC3 cells in vector-expressing but not FABP5 shRNA-expressing cells (red/blue and white bars). Data are presented as means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; (n ≥ 5).
