Figure 6
From: FABP5 coordinates lipid signaling that promotes prostate cancer metastasis
FABP5 is critical for FASN- and MAGL-mediated PCa metastasis in vivo. (A) Representative luciferase signals of PC3-Luc cells expressing vector, MAGL, or FASN on days 7 (D7) and 49 (D49). Signals are also shown for PC3-Luc cells expressing FABP5 shRNA (shFABP5) and those expressing FABP5 shRNA while overexpressing FASN (FASN/shFABP5) or MAGL (MAGL/shFABP5). (B) Total flux of vector and shFABP5 cells at the primary tumor site, whole mouse, and femurs. (C) Total flux of vector, FASN, and FASN/shFABP5 cells at the primary tumor site, whole mouse, and femurs. (D) Total flux of vector, MAGL, and MAGL/shFABP5 cells at the primary tumor site, whole mouse, and femurs. Data are presented as means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 vs. vector. #p < 0.05; ##p < 0.01; ###p < 0.001; ####p < 0.0001 represents FASN vs. FASN/shFABP5 or MAGL vs. MAGL/shFABP5; (n = 8).
