Figure 4 | Scientific Reports

Figure 4

From: Clinical Implications of Sub-grouping HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes

Figure 4

MYC, PPM1D and RPS6KB1 co-amplification with ERBB2. FAST analysis of low coverage whole genome sequencing (lcWGS) of two primary ER+/HER2+ breast tumors is visualized using Circus. The external ring represents chromosomal location; the inner ring shows areas of amplification as blue bars. Colored lines represent structural variations (SV), all the SV in an amplicon are colored with the same color. Although both tumors (P-5 and P-103) are primary breast ER+/HER2+ the co-amplified genes are different. In P-103 MYC co-amplification, colored green (panel A) while in P-5 PPM1D and RPS6KB1 co-amplification, colored green (panel B).

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