Table 2 HER2+ tumor samples characteristics.

From: Clinical Implications of Sub-grouping HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes

Sample#

Primary site

Stage

ER

ERRB2 Amplicon CN: WGS/ddPCR

ERBB2 Amplicon structure

Segment#

m-218

Colon

IV

N/A

17/20

DM

3

m-215

Breast

IV

−

22/17

DM

6

p-103* #1

Breast

LR

+

16/43

DM

2

m-119

Breast

IV

+

7/9

DM

10

p-6890

Gastric

IV

N/A

84/106

ID

18

p-104* #2

Gastric

IIIA

N/A

19/33

ID

1

p-8191

Gastric

IIIC

N/A

38/70

ID

2

p-2

Breast

IIA

−

21/67

ID

1

p-6

Breast

IIIC

−

20/70

ID

1

p-20

Breast

IIB

−

15/22

ID

1

p-22

Breast

IIA

−

29/140

ID

1

p-23

Breast

LR

−

29/44

ID

1

p-108* #2

Breast

LR

−

22/20

ID

1

p-114*

Breast

IIA

−

39/25

ID

3

p-216

Breast

IA

−

23/27

ID

1

p-5 #4

Breast

IIB

+

16/32

ID

1

m-12

Breast

IV

+

16/14

ID

4

p-13

Breast

IIA

+

19/44

ID

1

p-27

Breast

IIA

+

29/28

ID

1

p-29* #3

Breast

IV

+

30/25

ID

7

p-30

Breast

IA

+

12/21

ID

1

p-33 #4

Breast

IIB

+

26/36

ID

1

p-112

Breast

IIA

+

17/51

ID

1

p-203

Breast

IIB

+

21/24

ID

1

p-204

Breast

IIIA

+

13/9

ID

1

p-205

Breast

IIIA

+

9/12

ID

1

p-217

Breast

IV

+

20/37

ID

1

p-102* #1

Breast

IA

?

8/22

ID

1

p-16

Breast

IIA

−

15/51

n/a

1

p-21

Breast

IIB

−

9/10

n/a

1

p-25

Breast

IIB

−

15/21

n/a

1

p-28

Breast

IA

−

12/15

n/a

1

p-106

Breast

IIA

−

9/47

n/a

1

p-115

Breast

IIA

−

12/15

n/a

1

p-214

Breast

IIA

−

7/13

other

1

p-3

Breast

IIA

+

13/34

n/a

1

p-8

Breast

IA

+

9/13

n/a

1

m-11*#3

Breast

IV

+

16/126

n/a

1

p-17

Breast

IIA

+

10/90

n/a

1

p-209

Breast

IIB

+

10/17

other

1

  1. *Sample of a germline TP53 mutation carrier.
  2. #Sample from the same patient.
  3. p- sample from primary tumor; m- sample from metastatic tumor.
  4. Legend
  5. Sample – sample name.
  6. Primary site – organ from which the cancer originated.
  7. Stage – Stage of the patient at diagnosis according to the American Joint Committee on Cancer, 7th edition.
  8. ER – Estrogen receptor (ER) expression.
  9. ERRB2 Amplicon CN - WGS/ddPCR – Copy number of ERBB2 as measured by whole genome sequencing (WGS) and digital droplet PCR (ddPCR).
  10. ERBB2 Amplicon structure – Structure of the ERBB2 amplicon, either double minute (DM) or inverted duplication (ID).
  11. Segment # – Number of DNA segments composing the ERBB2 amplicon.