Figure 1

Schematic presentation of the mechanism for the homodimerization and activation of ErbB1 and ErbB2 and the inhibitory mechanism for the activation of ErbB2 by its antibodies. (a) A mechanism for ErbB1. (b) A mechanism for ErbB2. (c) Inhibitory mechanism for the activation of ErbB2 by trastuzumab and pertuzumab.