Figure 8

Schematic diagrams for the modes of action of nectin-4 on the signalling pathways of ErbB2 and its trastuzumab-resistant variants for DNA synthesis. (a) A mechanism for ErbB2. (b) A mechanism for p95-ErbB2. (c) A mechanism for ErbB2ΔEx16.
Schematic diagrams for the modes of action of nectin-4 on the signalling pathways of ErbB2 and its trastuzumab-resistant variants for DNA synthesis. (a) A mechanism for ErbB2. (b) A mechanism for p95-ErbB2. (c) A mechanism for ErbB2ΔEx16.