Table 3 Overview of EC50 values with associated standard errors and 95% confidence intervals (CI), and statistical significance calculated for the ITDR-CETSA curves in Fig. 4B,C.

From: CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance

Docetaxel

Imaging-CETSA

EC50 and St. Error (µM)

95% CI

Significance*

K562-P

0,12 ± 0,02

0,09-0,16

—

K562-R

0,83 ± 0,12

0,60-1,17

**

Paclitaxel

EC50 and St. Error (µM)

95% CI

Significance*

K562-P

0,08 ± 0,04

0,03-0,20

—

K562-R

2,00 ± 0,83

0,73-5,41

**

  1. *The significance was determined for K562-R vs. K562-P using a two-tailed T-test for EC50 values from independent experiments.
  2. P-values ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0,001, ****P < 0,0001 compared to K562-P.
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