Table 4 Overview of the statistical significance of the measured CETSA shift for the data presented in Fig. 5A–C.

From: CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance

MCF-7 Xenografts

β-tubulin

in vivo (60 °C)

Significance*

Vehicle

—

Docetaxel (50 mg/kg)

*

in vivo (60 °C)

Significance*

Vehicle

 

Docetaxel (16,5 mg/kg)

*

Docetaxel (33 mg/kg)

ns

Docetaxel (50 mg/kg)

**

ex vivo (62 °C)

Significance*

Vehicle

—

Docetaxel (50 µM)

*

  1. *The significance of the CETSA shifts was calculated using one-way ANOVA.
  2. Adjusted P-values ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0,001, ****P < 0,0001 compared to vehicle.
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