Figure 1

Place Learning Test of female Dusp8 WT and KO mice group-housed in the automated IntelliCage behavioral monitoring system. (A) Schematic of the place learning task. White corners contain water bottles freely accessible after a nose poke during the adaption phase (first 5 days). In the subsequent place learning task phase (duration 5 days), corners with blocked access to the water bottles after a nose poke are shown in grey. (B) Percentage of erroneous nose pokes in the first night phase as measure for the learning performance. Overall activity of the mice in the first night phase is monitored as bi-hourly number of corner visits (C), average number of corner visits (D) and average number of nose pokes (E). (F–I) depict the corresponding values from the second night of the place learning task. WT: n = 8, KO: n = 9. Means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.