Figure 1
From: A genetic development route analysis on MDS subset carrying initial epigenetic gene mutations
Distribution of initial and driver mutations. (a) Under the premise that the frequencies of the 3 initial mutations were very similar, the driver mutations were very different in patients with normal chromosomes or abnormal chromosomes (total 563 cases). Pink and red bar represents initial mutations (ASXL1, TET2 and DNMT3A) in patients groups with normal or abnormal karyotype, respectively. (b) Distribution of driver mutations in patients in C1 (114 cases, all with initial mutations). Driver mutations include U2AF1, SF3B1, RUNX1, BCOR, EZH2, TP53, etc. (c) Distribution of driver mutations in patients in C2 (85 cases, all with initial mutations). The frequencies of the U2AF1, SF3B1 and RUNX1 mutations were similar to those in C1, but that of BCOR mutations was lower, while that of EZH2/TP53 mutations was much higher.
