Table 1 Comparison of initial mutations for all 563 cases.
From: A genetic development route analysis on MDS subset carrying initial epigenetic gene mutations
Parameters | Normal chromo | Abnormal chromo | P |
|---|---|---|---|
Initial mutation number | 114/313 cases | 85/250 cases | |
Initial mutation (%) | 36.4 | 34.0 | 0.584 |
ASXL1 (%) (No) (exon12) | 16.0(50) (42/50) | 14.0(35)(31/35) | 0.878 |
DNMT3A (%) (No) (exon23) | 11.2(35) (13/35) | 10.8(27)(10/27) | 0.995 |
TET2 (%) (No) (exon3) | 13.4(42) (25/42) | 16.0(40)(21/40) | 0.734 |
Mean VAF (range) | 0.43(0.11–0.88) | 0.45(0.23–0.86) | |
ASXL1 + DNMT3A (no) | 3 | 2 | |
ASXL1 + TET2 (no) | 6 | 10 | |
DNMT3A + TET2(no) | 5 | 5 | |
ASXL1 + DNMT3A + TET2 (no) | 0 | 0 |
