Figure 10

Percentage of eQTLs that are trans-acting at (a) transcript-level and (b) exon-level by brain regions. Note that these numbers are corresponding to eQTLs that were found at the transcript-level (i.e. includes transcript-only and a subset of “both”) and at the exon-level (i.e. includes exon-only and a subset of “both”). Error bars of both plots are model-based standard errors. At the transcript-level (a), the percentage varies across the brain regions with the frontal cortex (FCTX) and white matter (WHMT) showing a low percentage (~20%) of trans-acting eQTLs while the substantia nigra (SNIG) and putamen (PUTM) show a higher percentage (≥50%). At the exon-level (b), it is important to consider the significant interaction of region and chromosome. The error bar for SNIG is not included and the error bar for the medulla (MEDU) is relatively large because for these regions, there are chromosomes with no trans-acting eQTLs (e.g. there are no exon-level trans-acting eQTLs on transcript Chr 21 in SNIG and MEDU).