Figure 4
From: Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo
More [13C5]-glutamine enters the TCA cycle in PIK3CA mutant tumors than adjacent normal tissue in orthotopic patient-derived xenografts. (A,B) [13C5]-glutamine tracing in orthotopic xenograft tumors established from a colon cancer patient-derived xenograft. The M5 enrichment of glutamine and the M4 enrichments of metabolites directly derived from M5 glutamine are shown in (A). Percentages of total 13C-labeled metabolited normalized to total 13C-labeled glutamine in tumors are plotted in (B). *p < 0.05, **p < 0.01; the Student’s t test.
