Figure 2 | Scientific Reports

Figure 2

From: R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome

Figure 2

Patch clamp of iPSC-derived cardiomyocytes. (a) Representative patch clamp recordings of potassium currents before and after treatment with E4031 in all groups. These currents were subtracted to obtain IKr (E4031-sensitive IK). (b) I-V graph showing IKr current densities for all cell lines. Control cardiomyocytes had significantly higher currents at 10, 20 and 30 mV compared to LQTS2 cardiomyocytes (*p < 0.05). (c) Average IKr tail current normalized to the maximal current following repolarization to −40 mV in CTRL-iPSC, LQTS2-iPSC1 and LQTS2-iPSC2. Voltage protocol used for patch clamp recordings of the representative currents is also shown.

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