Table 1 Topology prediction of MecR1 from Staphylococcus aureus NRS70.

From: An experiment-informed signal transduction model for the role of the Staphylococcus aureus MecR1 protein in β-lactam resistance

 

TopPred

HMMTOP

TMHMM

TMpred

DAS

MecR1 Staphylococcus aureus NRS70

TM regions

1

3–23

6–23

5–27

5–28

7–27

2

37–57

40–57

40–62

37–55

39–54

3

105–125

105–122

103–125

105–125

106–125

4

172–192

162–179

173–193

5

216–236

214–236

220–228

6

316–336

316–338

316–334

319–330

  1. Five distinct algorithms were used: TopPred, HMMTOP, TMHMM, TMpred and DAS, all available in www.expasy.org. Six transmembrane (TM) helical regions were found, with different confidence score levels regarding each algorithm. The numbers in black show the amino acid position in which the TM is located. Numbers in red correspond to TM helical regions predicted with a low score (below the cutoff stipulated in each algorithm).