Figure 2
From: Patterns of diverse gene functions in genomic neighborhoods predict gene function and phenotype
Semantically distant GO terms can be as strongly enriched in gene neighborhoods as the semantically close GO terms. Four example GO terms of the ‘Biological process’ ontology are shown. Histograms show numbers of GO terms at a certain log odds ratio (log OR) of the enrichment in gene neighborhood (for prokaryotic genomes). The GO terms in neighborhoods of a central GO function are broken down into three groups: the “CLPar” group (the central function itself plus all its parent functions in the GO graph), “CLMed” group (functions with Resnik semantic similarity >2 with the central function) and “Dist” group (Resnik ≤2 with the central function). Instances of GO terms in the dissimilar “Dist” group and in the non-self “CLMed” group can be observed that have enrichments as high or higher than the self-enrichments (the “CLPar” functions, arrows on the plot).
