Figure 4

Chemogenetic acute activation of PV⁺ neurons in the mPFC of PV:Cre male and female mice does not impact behaviors in the OF test. (Top) Experimental schematic of the timeline followed. Mice injected with the control (AAV-DIO-mCherry) or the AAV-DIO-hM3DGq virus received one injection of CNO 30 minutes prior to the OF. (A–C) Acute activation of mPFC PV⁺ neurons did not impact time spent in the center, locomotion near the walls or total locomotion in the novel arena in male and female mice. N = 8–9 per group per sex. OF: open field.