Table 3 Top diseases and functions of significant differentially expressed genes in treated vs. untreated GBM tissue.

From: Deep sequencing and automated histochemistry of human tissue slice cultures improve their usability as preclinical model for cancer research

Diseases and disorders

p-value

molecules of 2527 in total

Cancer

6.38 × 10−04 − 1.00 × 10−63

2306

- Tumorigenesis of tissue

1.29 × 10−62

2189

- Malignant solid tumor

4.32 × 10−58

2263

- Glioma

5.59 × 10−04

216

Organismal injury and abnormalities

6.38 × 10−04 − 1.00 × 10−63

2327

Gastrointestinal disease

4.31 × 10−04 − 2.00 × 10−56

2148

Hepatic system disease

4.31 × 10−04 − 2.09 × 10−39

1632

Reproductive system disease

1.93 × 10−04 − 2.98 × 10−36

1514

Molecular and cellular functions

Gene expression

5.07 × 10−08 − 6.05 × 10−13

514

Cellular assembly and maintenance

6.38 × 10−04 − 1.13 × 10−12

525

Cellular function and maintenance

3.19 × 10−04 − 1.13 × 10−12

406

Cell death and survival

6.22 × 10−04 − 1.36 × 10−10

778

Cell cycle

5.47 × 10−04 − 5.51 × 10−10

348

- Cell cycle progression

5.51 × 10−10

251

- Proliferation of tumor cells

6.38 × 10−04

99

Physiological system development

Organismal survival

9.88 × 10−13 − 1.30 × 10−13

554

Nervous system development and function

5.53 × 10−04 − 9.90 × 10−12

380

Tissue morphology

5.53 × 10−04 − 1.18 × 10−09

268

Organ morphology

4.31 × 10−04 − 1.10 × 10−08

255

Organismal development

4.35 × 10−04 − 1.10 × 10−08

551