Figure 1
From: Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor
Sexually dimorphic obesity and diabetes in CAR−/− mice. Body weight, monitoring, epidydimal (ep), subcutaneous (sc) white adipose tissue (WAT) weight in male (A) and female (B) CAR−/− mice (n = 18 per group). Glucose tolerance was assessed in male (C) and female (D) mice (12 weeks) via intraperitoneal glucose administration and at age 62 weeks via oral administration (n = 9 per group). Insulin tolerance was assessed in male (E) and female (F) mice at age 13 weeks (n = 6 per group). Fasted glycemia and insulinemia were assessed in male (E) and female (F) animals at age 33 week (n = 9 per group). Data are presented as mean ± s.e.m. *p < 0.05, ***p < 0.001.
