Figure 4
From: Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor
1H-NMR–based metabolic profiling of aqueous liver extracts. (A) PCA score plots derived from the hepatic 1H-NMR spectra from liver aqueous extracts of CAR−/− and WT males and females age 68 weeks. (B,C) Cross-validated score plots related to the O-PLS-DA models discriminating between WT and CAR−/− males (B) or females (C). (D,E) Coefficient plots related to the O-PLS-DA models discriminating between WT (bottom) and CAR−/− (top) males (D) or females (E). Metabolites are color-coded according to their correlation coefficient, and significantly altered metabolites are labeled (R2 > 0.5). The direction of the metabolite indicates the group with which it is positively associated, as labeled on the diagram. (F,G) Area under the curve (AUC) of the 1H-NMR signals of selected metabolites. Data are presented as the mean ± s.e.m. *p < 0.05, **p < 0.01, ***p < 0.00, n = 8 mice per group.
