Figure 6
From: Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor
Disruption of endocrine homeostasis in CAR−/− males and females. Plasmatic levels of testosterone in males and estradiol in females were assessed in WT and CAR−/− mice at 68 weeks (A). Plasma and urine corticosterone levels were analysed in male and female WT and CAR−/− mice (B).The relative gene expression of Hsd3b1, Hsd3b5, Hsd11b1, Akr1c14, Srd5a1 and Aldh3a2 was assessed by RT-qPCR in male and female WT and CAR−/− mice at age 68 weeks (C). Data are mean ± s.e.m. *p < 0.05, **p < 0.01, ***p < 0.001, n = 18 mice per group.
