Table 3 Comparisons of serum levels of ten endothelial function-related markers between preoperative and postoperative and between male and female.

From: Association between Upper-airway Surgery and Ameliorative Risk Markers of Endothelial Function in Obstructive Sleep Apnea

Variables

Preoperative

Postoperative

P value

Mean change (95%CI)

P value

Health

Male

Female

P value

 

Male

Female

VEGFA (pg/ml)

40.29 (37.94, 70.29)

43.67(39.24,65.55)

17.98(−33.10,159.47)

0.377

23.34 (25.94, 41.70)

20.19(25.52,43.22)

25.75(8.76,53.08)

0.875

−20.29 (−35.27, −5.31)

0.013*

69.8 ± 1154

VEGFR1 (pg/ml)

1160.96 (1054.77, 1563.63)

1.18(1.11,1.68)

0.60(0.25,1.44)

0.027*

1079.38 (1100.76, 1632.89)

1.28(1.18,1.77)

0.77(0.26,1.30)

0.062

57.63 (−120.85, 236.10)

0.852

1892 ± 120055

Ang1 (ng/ml)

6.84 (6.22, 7.46)

6.72(6.18,7.3)

6.87(4.10,10.63)

0.95

7.64 (6.81, 8.48)

6.87(6.71,8.62)

6.35(5.50,9.54)

0.975

0.81 (−0.01, 1.61)

0.07

3 ± 0.43256

Ang2 (ng/ml)

2.96 (2.87, 3.05)

2.95(2.86,3.07)

2.97(2.71,3.08)

0.637

2.89 (2.80, 2.98)

2.87(2.80,3.00)

2.91(2.66,3.06)

0.9

−0.06 (−0.16, 0.03)

0.042*

0.88 ± 0.457

ICAM1 (ng/ml)

1215.95 ± 380.88

0.37(0.35,0.43)

0.34(0.28,0.41)

0.489

1271.36 ± 358.78

0.33(0.31,0.39)

0.31(0.23,0.44)

0.73

55.41 (−83.66, 194.49)

0.426

312.58 ± 79.7758

VCAM (ng/ml)

188.53 (209.66, 346.77)

196.24(202.76,307.03)

167.37(−9.80,802.16)

0.925

176.02 (196.18, 266.89)

175.06(190.97,267.79)

176.98(121.95,363.88)

0.73

−46.68 (−108.63, 15.27)

0.176

975.35 ± 389.3258

E-selectin (ng/ml)

38.80 ± 17.99

32.43(30.61,42.62)

47.22(37.67,63.09)

0.035*

31.59 ± 15.21

27.20(25.36,35.56)

32.43(24.31,50.80)

0.228

−7.21 (−11.01, −3.41)

<0.001**

58.67 ± 24.0958

VWF (ng/ml)

289.44 (251.93, 326.94)

302.77(237.90,323.36)

304.48(276.27,385.15)

0.45

230.61 (190.73, 270.48)

207.13(193.76,282.98)

130.31(81.91,297.23)

0.377

−58.83 (−103.93, −13.73)

0.016*

134.65 ± 15.5458

VWFCP (ng/ml)

381.35 ± 115.74

375.73(348.12,429.30)

342.91(277.06,407.88)

0.489

347.83 ± 112.93

327.90(312.20,388.60)

307.99(231.34,437.22)

0.73

−33.52 (−66.34, −0.70)

0.046*

79.47 ± 10.7859

TM (ng/ml)

0.28 ± 0.12

0.27(0.24,0.31)

0.24(0.15,0.40)

0.778

0.22 ± 0.07

0.20(0.20,0.25)

0.20(0.17,0.24)

0.95

−0.06 (−0.09, −0.03)

0.001*

32.0 ± 67.660

  1. Abbreviations: VEGFA = vascular endothelium growth factor A, VEGFR1 = vascular endothelium growth factor receptor 1, Ang1 = angiopoietin-1, Ang2 = angiopoietin-2, ICAM1 = intercellular adhesion molecule-1, VCAM = vascular cell adhesion molecule, E-selectin = endothelial-leukocyte adhesion molecule, VWF = von willebrand factor, VWFCP = von willebrand factor cleavage protease, TM = thrombomodulin, CI = confidence interval.
  2. *p < 0.05.
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