Table 2 Number of somatic single-nucleotide mutation calls per Mb in lower lobe lung brushings of COPD cases and controls. Genome size was calculated based on positions with read depth ≥10 in both, reference and affected tissue. Ranges are given due to the small number of individuals per category.

From: High degree of polyclonality hinders somatic mutation calling in lung brush samples of COPD cases and controls

 

N

MuTect

VarScan 2

Strelka

Intersection

COPD cases

4

1.97–3.00

2.26–9.03

0.10–0.54

0.02–0.19

former smokers

5

1.36–12.17

1.79–5.00

0.14–0.95

0.03–0.12

never smokers

3

2.01–2.81

1.91–7.94

0.18–0.25

0.03–0.04

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