Figure 3
From: Anti-Nogo-A antibodies prevent vascular leakage and act as pro-angiogenic factors following stroke
Vascular leakage in the peri-infarct region in response to VEGF or anti-Nogo-A antibodies in whole brain images. (A) Dorsal view of representative brains with extravasated EB in and around the stroke cores with corresponding heatmap. Scale bar: 5 mm (B) Quantitative measure of area (top) and circumference (bottom) of the EB leakage in the stroke core (C) and in the peri-infarct zone. Brain templates visualize local EB distribution from single animals in the core (green) and peri-infarct zone (purple). Data are represented as mean ± SD. Each dot in the plots represents one animal and significance of mean differences between the groups was assessed using Tukey’s HSD. Asterisks indicate significance: *P < 0.05, **P < 0.01, ***P < 0.001.
