Figure 5
From: Anti-Nogo-A antibodies prevent vascular leakage and act as pro-angiogenic factors following stroke
Maturation and tight junction composition of the endothelium in the ischemic border zone. (A) Schematic composition of blood brain barrier with the vasculature, pericytes, astrocyte end feet, neurons and the tight junction proteins (VE-Cadherin, ZO-1, Claudin-5). (B) Fluorescence images of the vascular endothelium with pericytes (CD13) and tight junction proteins (ZO-1 and VE-Cadherin). Scale bar = 5 µm. (C) Quantitative assessment of endothelial coverage with pericytes and tight junction proteins in the peri-infarct region. Data are represented as mean ± SD. Differences between the groups were assessed using Tukey’s HSD. Asterisks indicate significance: *P < 0.05, **P < 0.01, ***P < 0.001.
