Figure 2

Cell adhesion- and ECM related-genes are significantly up-regulated upon Sox2 overexpression in Schwann cells. (a) Heat map of the normalized overlapping genes differentially expressed in four selected Sox2-positive Schwann cell clones (SC^Sox2/Cl1, SC^Sox2/Cl2, SC^Sox2/Cl3, SC^Sox2/Cl4) compared to the wild type (SC^wt). The top significantly up- and downregulated ECM-related genes are highlighted. (b) Venn diagram of differentially regulated genes in Sox2 clones. (c,d) Gene ontology (GO) enrichment analysis for biological process and cellular components for the up-regulated overlapping genes in four Sox2-positive clones (SC^Sox2/Cl1, SC^Sox2/Cl2, SC^Sox2/Cl3, SC^Sox2/Cl4). (e) Literature-derived network of ECM related genes involved in cell adhesion and migration showing Fn1 as a highly interconnected gene within the network. Probes with a p-adjusted < 0.002 and 2 < fold change (FC) <−2 were considered for the analysis.