Figure 3
From: In silico analysis of alternative splicing on drug-target gene interactions
Multiple sequence alignments of predicted interacting residues of Erlotinib on different isoforms of EGFR protein. Cluster Omega was applied to align the binding residues with isoform sequences using Bioconductor package msa. From top to down: predicted Imatinib interacting residues; aligned Pfam domains (different versions represent different sequences with same Pfam ID); EGFR-206; EGFR-203; EGFR-207; EGFR-205; EGFR-202; EGFR-204 and EGFR-201. Sequence logo of the consensus sequences were shown on top of each line. Blue shading indicates overlapping residues of a sequence with the predicted binding residues. Purple shading indicates ≥50% of all sequences are conserved with this residue. Pink shading indicates similar amino acids. Only regions near the predicted binding pockets were shown.
