Figure 5
From: In silico analysis of alternative splicing on drug-target gene interactions
Multiple sequence alignments of predicted interacting residues of PD-0325901 on different isoforms of MAP2K1 protein. Cluster Omega was applied to align the binding residues with isoform sequences using Bioconductor package msa. From top to down: predicted Imatinib interacting residues; aligned Pfam domains (different versions represent different sequences with same Pfam ID); MAP2K1-201 and MAP2K1-203. Sequence logo of the consensus sequences were shown on top of each line. Blue shading indicates overlapping residues of a sequence with the predicted binding residues. Purple shading indicates ≥50% of all sequences are conserved with this residue. Pink shading indicates similar amino acids.
