Figure 6
Representative example of an Oncotype Dx report. The sample report downloaded from Genomic Health represents the former version not adapted to the results of the TAILORx study, but the highlighted discrepancies still appear in the novel reports. It is claimed that the single gene expression scores of ER, PR and HER2 are included in the RS calculation (green), although only normalized Ct values were described to be included in the RS calculation. Moreover, single gene expression scores lack an internationally accepted unit (blue) and the origin of the thresholds (red) remains unclear even if all references in the entire citation chain were followed, starting with the references mentioned in the report’s footnotes. Whilst on the report’s top it is mentioned that other methods or assays from other laboratories may differ from the results reported, it is claimed on the bottom that the Her2 score was evaluated against two other methods (yellow).
