Table 1 Clinical, serological, and pathological characteristics of the NAFLD patients.

From: Tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis: a novel glycobiomarker for non-alcoholic steatohepatitis

 

NAFL

NASH

P value

N

57

74

 

Male (%)

68.4

43.2

<0.01

Age (Yr)

48 ± 15

55 ± 15

<0.01

BMI (kg/m2)

28 ± 4

30 ± 6

NS

Plt (104/μL)

22 ± 6

20 ± 7

NS

Albumin (g/dL)

4.4 ± 0.3

4.2 ± 0.4

<0.01

T-bil (mg/dL)

0.8 ± 0.4

0.8 ± 0.3

NS

AST (IU/L)

50 ± 24

67 ± 38

<0.01

ALT (IU/L)

93 ± 67

86 ± 64

NS

ChE (U/L)

379 ± 92

328 ± 121

NS

γ-GTP (IU/L)

97 ± 113

82 ± 59

NS

AFP (ng/mL)

2.4 ± 1.8

3.5 ± 2.7

NS

TG (mg/dL)

174 ± 83

158 ± 79

NS

LDL-C (mg/dL)

131 ± 29

114 ± 39

<0.05

HDL-C (mg/dL)

50 ± 15

45 ± 16

NS

HbA1c (%)

5.9 ± 0.7

6.2 ± 1.8

<0.001

FBS (mg/dL)

106 ± 26

123 ± 45

<0.05

IRI (μIU/L)

20.0 ± 30.5

14.1 ± 11.1

NS

HOMA-IR

5.7 ± 9.3

4.5 ± 4.4

<0.05

cCK18 (U/L)

572 ± 359

927 ± 698

<0.01

M2BPGi (COI)

0.73 ± 0.66

1.24 ± 0.95

<0.001

FIB4 index

1.55 ± 1.4

2.31 ± 1.53

<0.001

APRI

0.60 ± 0.34

0.94 ± 0.69

<0.001

Pathological findings

Steatosis (0/1/2/3)

0/23/22/12

0/23/30/21

 

Lobular inflammation (0/1/2/3)

24/30/3/0

0/38/31/5

 

Ballooning (0/1/2)

54/2/1

1/46/27

 

Fibrosis (0/1/2/3/4)

30/27/0/0/0

2/37/10/23/2

 
  1. Data are presented as mean ± SD. P values correspond to the comparison between NAFL and NASH groups. Mann Whitney U tests for continuous factors and Fisher’s exact test for categorical factors were used. Abbreviations: NAFL, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis.