Table 2 Summary of IC50s for pharmacological inhibitors of T-type VGCCs on lymphatic contraction amplitude and frequency.

From: T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions

Drug

Species

LV location

IC50 for amplitude

IC50 for frequency

Mibefradil

Rat

Mesenteric

66 nM

423 nM

Ni2+

Rat

Mesenteric

248 µM

279 µM

Mouse

IAL

66 µM

1287 µM

Mouse

Popliteal

110 µM

452 µM

TTA-A2

Mouse

Popliteal

1.3 µM

nd

  1. nd = not-determined.
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