Figure 7
Keap1 deficient mice exhibit increased bone mineralization in male Keap1+/− newborn mice compared to WT newborn mice. Newborn pups were stained with Alcian blue/Alizarin red. Bone is stained red and cartilage blue. Neurocranium, limbs and spine were detected. Limbs showed accelerated skeletal mineralization in fingers and toes (black arrows) in Keap1 heterozygotes and knockout newborn mice in comparison with their wild type control.
