Figure 3
From: Recombinant thrombomodulin prevents acute lung injury induced by renal ischemia-reperfusion injury
Proinflammatory gene mRNA expression in the lungs and kidneys after renal IR. Bilateral renal IR model mice (30-min ischemia followed by 24 hours of reperfusion) were pretreated with saline (IR group) or 10 mg/kg of rTM (IR + rTM group). Pulmonary mRNA expressions of (a) TNF-α, (b) IL-6, and (c) KC were shown. The mRNA expressions of (d) TNF-α, (e) IL-6, (f) KC, and (g) NGAL were also evaluated in the IR-injured kidney. n = 5 per group. *P < 0.05 versus respective control. Abbreviations: IL, interleukin; IR, ischemia-reperfusion; KC, keratinocyte-derived chemokine; mRNA, messenger RNA; NGAL, neutrophil gelatinase-associated lipocalin; rTM, recombinant thrombomodulin; TNF-α, tumor necrosis factor-α.
