Figure 1 | Scientific Reports

Figure 1

From: Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients

Figure 1

Workflow of the experimental design. The EPOS series was divided in two groups according to the nausea vomiting score (NVS). Pool 1 – low: patients characterized by NVS < 33.3 (no or low nausea and vomiting); Pool 2 – high: patients with NVS ≥ 33.3 (moderate or high nausea and vomiting). DNA pools were genotyped by exome sequencing. Then, the technical validation of 48 selected SNPs was carried out by individual genotyping. Finally, we replicated the study of the selected SNPs in an independent patient series (CERP).

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