Figure 4
From: Quantifying Reoxygenation in Pancreatic Cancer During Stereotactic Body Radiotherapy
Tumour growth inhibition was greater for tumours that reoxygenated more during radiotherapy. Mean scaled tumour volumes—volumes divided by volumes at the start of radiation—are shown as a function of time after the end of radiotherapy for irradiated tumours segregated into two groups based on reoxygenation: ΔHF1.4 < −0.09 (the median value for ΔHF1.4) and ΔHF1.4 > −0.09. Error bars indicate the standard deviation of scaled tumour volumes in each group. The number of mice n in each group are shown above and below error bars; where not shown, n = 6. The analogous plots using ΔHF3σ are essentially the same. Mann-Whitney U test p-values were 0.08, 0.12, 0.02, and 0.02, 0.053 at 50, 100, 127, 183, and 219 days after completion of SBRT, respectively. The test was not significant (p > 0.05) at the last volume measurement (219 days post-SBRT) because only 4 mice lived to this time.
