Figure 5
From: Quantifying Reoxygenation in Pancreatic Cancer During Stereotactic Body Radiotherapy
Bimodal MR signal enhancement in SPGC35 mice. Representative DCE-MR images (1 minute post-injection) before (a), after (b) SBRT from a second-cohort mouse, and from a first-cohort mouse at 4 months post-SBRT (c). The tumour contours are shown by the red lines. The spatial enhancement patterns are suggestive of high levels of solid stress in central regions, occluding blood vessels pre-SBRT, partial central de-occlusion post-SBRT, and substantial hypoperfusion throughout the entire tumor late post-SBRT. (d–f) Example bimodal fits (solid lines) to binned voxel-scale MRI signal enhancement data 60 s after contrast injection for the full volumes of the tumours shown in (a–c). The unperfused volume fractions vu from the fits are: 0.44, 0.17, and 0.63 respectively. The individual “modes” in the bimodal fits—as well as their sums—are presented as separate filled distributions.
