Figure 2
From: Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway
ATE1 expression is upregulated by hypertrophic stimuli. (A) Quantitative real-time PCR analysis of mRNA levels of ATE1 in Ang II treated H9C2 cells. (B) Transcriptional levels of ATE1 in heart samples from rat subjected to ligation of right renal artery (Ligated) and sham-operated control (Sham) rats. (C) Western blot analysis of ATE1 protein levels in heart samples from sham and renal ligated rats. Data were derived from experiments performed in triplicate and normalized to GAPDH content. Statistical analysis was carried out by student’s two-tailed t-test (*shows non-specific binding of antibody).
