Figure 2

Distribution of CRBN variants in subjects with Thalidomide Embryopathy, by gene position and genotypes. (A) Number of variants in the CRBN gene in each subject with TE, and their respective gene location; (B) Genotypes of the CRBN variants in each subject with TE. Yellow: Ref/Ref – individual does not present the variant; Orange: Ref/Alt – individual is heterozygous for the variant; Red: Alt/Alt – individual is homozygous for the variant.