Figure 5

Cereblon gene and protein conservation across different vertebrate species (top) alignment of CRBN CULT-domain coding region and translated protein (bottom). Species affected by typical TE are Homo sapiens (human), Macaca mulatta (Rhesus monkey), Macaca fascicularis (crab-eating monkey), Oryctolagus cuniculus (rabbit), Gallus gallus (chicken) and Danio rerio (zebrafish). The rodents Rattus norvegicus (rat) and Mus musculus (mouse) do not present typical TE, after exposure to thalidomide during embryonic development. Nucleotides (top) and amino acids (bottom) alignment between the eight species studied. Only synonymous mutations are identified in the region. Source: UNIPROT.