Table 1 Literature main findings for CRL4CRBN-thalidomide interaction and induced protein effect.
From: CRL4-Cereblon complex in Thalidomide Embryopathy: a translational investigation
Pubmed ID | Protein Interaction | IMiD tested in the study | Is the mechanism IMiD dependent? | IMiD-protein interaction effect* |
|---|---|---|---|---|
27142104 | AGO2 | lenalidomide | yes | alters expression. |
26990986 | GS | none | no | |
27294876 | CD147 | none, Thal, Len, Pom | no | competition for CRBN binding reduces expression |
27294876 | MCT1 | none, Thal, Len, Pom | no | competition for CRBN binding reduces expression |
26021757 | CLC1 | none | no | |
19295130 | DDA1 | none | no | |
24292623 | IKZF1 | Thal, Len, Pom | yes | induced degradation |
24292623 | IKZF3 | Thal, Len, Pom | yes | induced degradation |
27468689 | TAB2 | none | no | |
27468689 | TRAF6 | none | no | |
25043012 | MEIS2 | lenalidomide | no | block MEIS2 binding to CRBN |
21232561 | AMPKA1 | none | no | |
23026050 | PSMB4 | none | no | |
27601648 | RABGEF1 | lenalidomide | no | prevents association to CRBN |
31591562 | TP63 | thalidomide | yes | neosubstrate of thalidomide-CRBN |
30067223 | SALL4 | Thal, Len, Pom | yes | thalidomide-CRBN induced degradation (C2H2 motif) |
