Table 3 Relative Risk of microbleed by location and radiation dose, adjusting for age at diagnosis and sex.

From: Cerebral microbleeds in adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation

Presence of microbleeds

levels

Relative Risk (95% CI)

P-value

Frontal lobe

24 Gy vs 18 Gy

1.92 (1.41, 2.61)

<0.001

Limbic/Temporal lobe

24 Gy vs 18 Gy

2.12 (1.52, 2.95)

<0.001

Occipital/Parietal lobes

24 Gy vs 18 Gy

2.73 (1.72, 4.31)

<0.001

Anterior/posterior/Medulla, Pons

24 Gy vs 18 Gy

1.95 (1.18, 3.22)

0.013

Sub-lobara/Midbrain

24 Gy vs 18 Gy

2.24 (1.43, 3.52)

0.001

Top tertile of total number of microbleeds (6 or more)

24 Gy vs 18 Gy

5.15 (2.57, 10.32)

<0.001

  1. aSub-lobar denotes the region filling the remaining undefined volume within each hemisphere.
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