Table 6 Neuropsychological testing outcomes by location of microbleeds, adjusting for age at diagnosis and sex.
Neurocognitive Outcome | Frontal lobe | Limbic/Temporal lobe | Occipital/Parietal lobe | Cerebellum/Brainstem | Sub-lobar/Midbrain | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Est (SE) | P | Est (SE) | P | Est (SE) | P | Est (SE) | P | Est (SE) | P | |
Location of microbleed | ||||||||||
Verbal ability | 0.21 (0.26) | 0.42 | 0.38 (0.26) | 0.14 | 0.07 (0.26) | 0.80 | 0.26 (0.26) | 0.33 | 0.13 (0.26) | 0.61 |
Cognitive flexibility | 0.10 (0.32) | 0.77 | 0.21 (0.32) | 0.52 | 0.03 (0.32) | 0.93 | −0.09 (0.33) | 0.78 | 0.23 (0.32) | 0.48 |
Dominant motor speed | −0.09 (0.24) | 0.72 | 0.11 (0.24) | 0.65 | −0.05 (0.24) | 0.84 | 0.10 (0.24) | 0.69 | −0.25 (0.24) | 0.31 |
Non-Dom motor speed | −0.24 (0.27) | 0.37 | 0.09 (0.26) | 0.72 | −0.33 (0.26) | 0.22 | −0.06 (0.27) | 0.81 | −0.19 (0.27) | 0.49 |
Memory span | −0.11 (0.23) | 0.65 | 0.17 (0.23) | 0.47 | 0.17 (0.23) | 0.47 | 0.09 (0.23) | 0.70 | 0.19 (0.23) | 0.41 |
Working memory | −0.05 (0.22) | 0.83 | 0.11 (0.21) | 0.60 | 0.23 (0.21) | 0.28 | 0.15 (0.22) | 0.48 | 0.21 (0.22) | 0.34 |
Visual-motor speed | −0.11 (0.17) | 0.51 | −0.04 (0.17) | 0.81 | 0.01 (0.17) | 0.93 | −0.27 (0.17) | 0.11 | −0.17 (0.17) | 0.33 |
Processing Speed | −0.22 (0.20) | 0.29 | −0.21 (0.20) | 0.29 | −0.04 (0.20) | 0.84 | −0.32 (0.20) | 0.12 | −0.31 (0.20) | 0.12 |
Reading | −0.04 (0.11) | 0.71 | −0.10 (0.10) | 0.33 | −0.13 (0.10) | 0.22 | 0.08 (0.11) | 0.46 | 0.01 (0.11) | 0.91 |
Math | 0.05 (0.19) | 0.78 | 0.17 (0.19) | 0.36 | −0.07 (0.19) | 0.72 | −0.05 (0.19) | 0.80 | 0.01 (0.19) | 0.94 |
BRIEF Self-reporta | ||||||||||
Behavioral flexibility | 0.07 (0.25) | 0.77 | 0.34 (0.24) | 0.16 | 0.53 (0.24) | 0.031 | 0.39 (0.25) | 0.12 | 0.32 (0.25) | 0.20 |
Working memory | −0.01 (0.28) | 0.97 | 0.14 (0.27) | 0.61 | 0.58 (0.27) | 0.033 | 0.77 (0.27) | 0.005 | 0.12 (0.28) | 0.68 |
