Table 3 Comparative analysis of the circulating Tfh subsets in patients with sarcoidosis and healthy control.
From: Imbalance in B cell and T Follicular Helper Cell Subsets in Pulmonary Sarcoidosis
Tfh subset | Phenotype | Sarcoidosis (n = 37) | Healthy control (n = 35) | Significant differences |
|---|---|---|---|---|
CXCR3 − CCR6 − CCR4− Tfh | CXCR3 − CCR6 − CCR4− | 13.84 (10.57; 17.70) | 12.26 (8.98; 15.30) | 0.281 |
Tfh2 | CXCR3 − CCR6 − CCR4+ | 6.90 (5.31; 8.65) | 4.67 (3.80; 5.50) | ↑ <0.001 |
Tfh17 | CXCR3 − CCR6 + CCR4− | 20.81 (17.15; 26.11) | 22.64 (17.52; 27.77) | 0.299 |
CCR4+ Tfh17 | CXCR3 − CCR6 + CCR4+ | 14.53 (10.72; 19.73) | 10.67 (9.07; 12.86) | ↑ <0.001 |
Tfh1 | CXCR3 + CCR6 − CCR4− | 22.16 (17.20; 26.53) | 27.07 (21.22; 32.43) | ↓ 0.015 |
CXCR3 + CCR6 − CCR4+ Tfh | CXCR3 + CCR6 − CCR4+ | 5.27 (3.64; 6.25) | 3.73 (3.20; 4.95) | ↑ 0.047 |
Tfh17.1 | CXCR3 + CCR6 + CCR4− | 10.11 (8.35; 14.16) | 14.07 (10.68; 20.01) | ↓ 0.004 |
DP Tfh17 | CXCR3 + CCR6+CCR4+ | 3.43 (2.41; 4.99) | 2.76 (1.75; 3.32) | ↑ 0.006 |
